Observation on the effects of Chinese medicine zhenxuanyin for improving cerebral blood flow in rats with cerebral ischemia
Jingyi, W.; Yasuhiro, M.; Naoya, H.; Seok, R.C.; Yoshiharu, Y.; Nagara, T.; Fumiko, T.; Shigeru, M.; Junji, K.
Journal of Traditional Chinese Medicine 17(4): 299-303
1997
ISSN/ISBN: 0255-2922 PMID: 10437217 Document Number: 481533
Zhenxuanyin [symbol: see text] is composed of pure Chinese medicinal herbs, such as gastrodia tuber, poria cocos, ligusticum wallichii etc. 4-verssel occlusion (4VO) model rats were reperfused after 30 minutes' complete occlusion, and Zhenxuanyin was administered 3 times a day. 24 hours later, 123I-IMP uptake in the brain was evaluated as an index of cerebral blood flow (CBF). The results show that Zhenxuanyin (0.03 g/kg, 0.3 g/kg, 1 g/kg, or 3 g/kg a day) can greatly improve the blood flow in the main cerebral regions, and 0.3 g/kg can increase cerebral blood flow (CBF) to the normal level.