Local cerebral blood flow, cortical impedance, cerebral intravascular kinin production during forebrain ischemia and reperfusion in rats
Semeniutin, V.B.; Zubkov, I.N.; Lomova, I.P.; Eremeev, V.S.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 86(4): 410-421
2000
ISSN/ISBN: 0869-8139 PMID: 10870216 Document Number: 524475
In the rat model of forebrain ischemia with subsequent reperfusion, an obvious formation of intravascular kinin (IVKF) occurred. The IVKF preceded and coincided in time with the maximum hyperemia and a vasogenic oedema. Local cerebral blood flow (LCBF) increased up to about 187%, at that. In three groups of experimental rats, a correlation was revealed among the ischemia obviousness, IVKF, and development of the brain oedema.