Effect of diazinon and/or praziquantel on selected protein aspects in healthy and Schistosoma mansoni infected mice
Hanna, L.S.; Medhat, A.M.; Abdel-Menem, H.A.
Journal of the Egyptian Society of Parasitology 33(1): 145-162
2003
ISSN/ISBN: 1110-0583 PMID: 12739808 Document Number: 555526
A study was conducted to investigate the effect of 1/20 LD50 diazinon given orally to healthy and Schistosoma mansoni-infected mice for 5 successive days up to 9 and 17 weeks, coupled with a therapeutic dose (2x500 mg/kg body weight) of praziquantel. The results showed that non-significant differences in total proteins, albumin, globulin and albumin:globulin ratio. However, significant differences were observed in alpha 1-, alpha 2-, beta 1-, beta 2- and gamma -globulins in addition to plasma ceruloplasmin. Diazinon changed the levels of alpha 2-, beta 1-, and gamma globulins, while diazinon coupled with schistosomiasis affected the levels of most studied parameters. It is concluded that exposure to insecticides should be avoided especially in the rural areas where schistosomiasis is evident.