Praziquantel inhibits Schistosoma mansoni attachment in vitro
Da-Silva, S.P.; Noel, F.
Brazilian Journal of Medical and Biological Research 23(10): 1005-1008
1990
ISSN/ISBN: 0100-879X PMID: 2101049 Document Number: 358704
Male adult Schistosoma mansoni worms were placed in a glass dish containing Tyrode solution and observed for 15 min after addition of praziquantel (0.01 to 1 microM). Praziquantel promoted a concentration- and time-dependent inhibition of sucker-mediated attachment of the worm. Attachment inhibition was correlated with shortening of the parasite. We propose that the rapid and total inhibition of worm attachment observed in vitro with 1 microM praziquantel indicates that therapeutic concentrations of this drug should promote a rapid hepatic shift, in vivo, which may facilitate host tissue reaction.