Stimulation of Schistosoma mansoni oviposition in vitro by animal and human portal serum
Wu, G.Y.; Wu, C.H.; Dunn, M.A.; Kamel, R.
American Journal of Tropical Medicine and Hygiene 34(4): 750-753
1985
ISSN/ISBN: 0002-9637 PMID: 4025688 Document Number: 259849
Coupled adult pairs of Schistosoma mansoni were incubated in medium containing either peripheral or portal serum from rat, rabbit, hamster or humans. Daily egg production was measured. In all cases egg production was significantly increased for pairs in the presence of portal sera compared with that in the presence of peripheral sera. Fractionation of rabbit portal serum according to molecular weight demonstrated that the most active component(s) were in the range of 2000-50,000. These fractions were as effective in stimulating oviposition as whole portal serum. Portal serum factor(s) that stimulate S. mansoni oviposition are present in susceptible and non-susceptible hosts. The molecular weight range for the active components is larger than would be expected for simple carbohydrates, amino acids or free acids absorbed from the gastrointestinal tract.