Failure at inducing resistance to schistosomicidal drugs in a Brazilian human strain of Schistosoma mansoni
Dias, L.C.; Olivier, C.E.
Revista do Instituto de Medicina Tropical de Sao Paulo 28(5): 352-357
1986
ISSN/ISBN: 0036-4665 PMID: 3589395 Document Number: 270343
In this work, an attempt was made to inducing resistance to 3 schistosomicidal drugs in a Brazilian strain of Schistosoma mansoni, according to the Type II resistance induction scheme proposed by JANSMA et al. in 1977. Three attempts were unsuccessful. The parental generation treated with the drug during the immature stage of the worm was less susceptible to the chemotherapeutic agents than generations F1 and F2. A hypothesis is suggested as an explanation.
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