The in vivo disposition of diethyllipoamide
Xia, S.X.; Xu, H.Y.; Chen, N.Q.; Shen, B.F.
Zhongguo Yao Li Xue Bao 3(2): 136-139
1982
ISSN/ISBN: 0253-9756 PMID: 6214148 Document Number: 191649
The total radioactivity in mouse plasma and bone marrow after i.m. injection of [35S]diethyllipoamide was closely related to the radioprotective effects. Analysis of blood samples with paper radiochromatography and scanning showed that the active form of the drug in vivo was diethyllipoamide per se. The drug passed rapidly into the brain and was mainly distributed in liver and kidney. Approximately 53% of the radoactivity was excreted in urine within 24 h. The characteristics of drug distribution in these tissues were believed to be responsible for the transient toxic signs after large doses.
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