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The effect of methylbromophenvinfos (Polfos) on some enzymes in vivo and in vitro. I. In vivo studies

Pawłowska, D.; Koćmierska-Grodzka, D.; Moniuszko-Jakoniuk, J.

Polish Journal of Pharmacology and Pharmacy 39(4): 361-370

1987

ISSN/ISBN: 0301-0244
PMID: 2453047
Document Number: 297856
The experiment was carried out on Wistar rats receiving orally either oil or oily solution of methylbromophenvinfos (Polfos) either in a single dose of 0.5 LD50, or doses of 0.1 LD50 once daily for a period of 2, 4 or 6 weeks. The activities of cholinesterase (ChE), .beta.-glucuronidase (.beta.-glu), lipase and amylase were assayed in the blood serum, the activity of acetylcholinesterase (AChE) - in brain homogenates, and the activities of lipase and amylase - in homogenates of the pancreas. Cholinesterases were inhibited in the course of both acute and chronic poisoning with Polfos. During the acute poisoning a sharp increase in the activity of .beta.-glu in the blood serum, 1 and 2 h after the pesticide administration, was observed. Polfos inhibited lipase and amylase both after acute and chronic treatment.

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