The effect of estradiol on human endometrial cancer. Experimental in vivo and in vitro studies
Horvath, G.
Lakartidningen 97(22): 2746-2750
2000
ISSN/ISBN: 0023-7205 PMID: 10900896 Document Number: 514839
In this article our findings concerning estradiol-induced changes in steroid receptor activation, cell kinetics and tumor growth regulation during in vivo and in vitro progression of human endometrial adenocarcinomas are reviewed. We found major changes such as alterations in estrogen receptor function and post-receptor alterations in tumor growth regulation. Our results suggest that although the development of these alterations is genetically determined, they may to some extent be modified by circulating estradiol levels. No biological changes were found, suggesting that the use of menopausal estrogen replacement therapy by women with non-diagnosed endometrial cancer may increase their death rate.