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Synthesis of lipid a analogs. Obtaining conjugates of 6-phosphate 2-desoxy-2- (3-hydroxymyristoyl) amino-D-glucose with polymer carriers and their immunological properties

Gorbach, V.I.; Luk'ianov, P.A.; Solov'eva, T.F.; Ovodov, I.S.

Bioorganicheskaia Khimiia 11(5): 677-682

1985

ISSN/ISBN: 0132-3423
PMID: 3899123
Document Number: 254234
The derivatives of 2-acylamino-6-O-(2-aminoethyl) phosphono-3-deoxy-D-glucose acylated with acetic or D,L-3-hydroxytetradecanoic acid were obtained, and their 31P-and 13C-NMR spectra investigated. These haptens were bound with a polysaccharide (Ficoll) or proteins (albumins, bovine gamma-globulin). The protein conjugates were immunogenic in rabbits, specific antibodies against the hapten being revealed by two immunochemical methods. As shown by the enzyme-linked immunoadsorbent assay, the specific rabbit antiserum reacted with lipid A from Yersinia pseudotuberculosis.

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