Chymotrypsin-catalyzed fragment coupling synthesis of GnRH-analogs
Hänsicke, A.; Krause, E.; Bienert, M.; Schmidt, M.; Kobert, S.; Schellenberger, V.; Jakubke, H.D.; Kaufmann, K.D.
Biomedica Biochimica Acta 50(10-11): S201-S204
1991
ISSN/ISBN: 0232-766X PMID: 1820046 Document Number: 372693
D-Xaa6-GnRH analogs (Xaa: Ala, Nal1), Phe, Ser(tBu), Trp) were prepared by chymotrypsin catalyzed 3 + 7 fragment coupling synthesis with conversion rates of the amino component in the range from 90.3 to 97.4%. For D-Phe6-GnRH the method was scaled up to production level.
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