Synthesis of 5'-phosphatidylnucleosides by phospholipase D-catalyzed transphosphatidylation
Shuto, S.; Ueda, S.; Itoh, H.; Endo, E.; Fukukawa, K.; Imamura, S.; Tsujino, M.; Matsuda, A.; Ueda, T.
Nucleic Acids Symposium Series 17: 73-76
1986
ISSN/ISBN: 0261-3166 PMID: 3562280 Document Number: 275747
Phospholipase D from Streptomyces effectively catalyzed the transfer reaction of the phosphatidyl residue from phosphatidylcholine to the 5'-hydroxyl group of nucleosides. A variety of 5'-phosphatidylnucleosides were prepared by this reaction in high yields. Some of them showed marked antitumor activities in mice.
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