Inhibitory effect of various analogs of nucleoside-5'-triphosphates on DNA synthesis catalyzed by DNA polymerase from herpes simplex virus type i
Kilesso, T.I.; Shobukhov, V.M.; Papchikhin, A.V.; Galegov, G.A.
Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 10: 41-44
1987
ISSN/ISBN: 0208-0613 PMID: 2828934 Document Number: 297111
The effect of nucleoside-5-triphosphates analogues on the DNA polymerase of herpes simplex virus (HSV) has been investigated. Evidence is obtained that 3-amino-2,3-dideoxythymidine triphosphate selectively inhibits the DNA synthesis, catalyzed by HSV DNA polymerase. 3-amino-2,3-dideoxythymidine exhibits antiherpetic effect in single cells cultures. It may be phosphorylated by cellular thymidine kinase. The nuclei of Vero cells infected by HSV are an adequate system for antiherpetic compounds screening.
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