A helix-destabilising protein from herpes simplex virus type I infected cells which specifically stimulates the virus induced DNA polymerase activity in vitro

Bruce, C.B.; Pearson, C.K.

Biochemical and Biophysical Research Communications 116(1): 327-334

1983


ISSN/ISBN: 0006-291X
PMID: 6315006
Document Number: 200280
A protein fraction was isolated from herpes simplex virus type 1 (HSV-1) infected [hamster kidney BHK-21] cells which binds specifically to single-stranded DNA, facilitates a lowering of the melting temperature of poly[d(A-T)] and specifically stimulates the activity of the homologous virus-induced DNA-dependent DNA polymerase in vitro. These are major characteristics of a helix-destabilizing protein, exemplified by the prokaryotic gene 32 protein.

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