Differences in inhibition of apoptosis depending on the virulence of used herpes simplex virus type 1 strains. Function of interferon alpha in apoptotic death of virus infected cells
Rechnio, M.; Litwińska, B.ła.
Acta Microbiologica Polonica 52(3): 271-276
2003
ISSN/ISBN: 0137-1320 PMID: 14743979 Document Number: 558047
The purpose of the present study was to determine whether there is the relation between the virulence of used HSV-1 strains and inhibition of apoptosis. HEp-2 cells were induced to apoptosis by osmotic shock after infection by HSV-1 strains. HSV-1 ts, earlier described as less virulent for mice inhibited apoptosis in smaller degree than native strain and HSV-1 tr. We suggest that this is due to the hyperproduction of IFN alpha by human cells after the stimulation by this strain. All strains of HSV-1 didn't inhibit apoptosis in the presence of IFN alpha and apoptosis was inhibited by anti IFN alpha antibodies. We confirm that IFN alpha plays an important function in controlling acute HSV-1 infection.