S-7 inhibition of Herpes simplex virus type 1 infectivity and replication in cultured cells
Muratore, O.; Pesce-Schito, A.; Mosti, L.; Sansebastiano, L.; Schito, G.C.
Journal of ChemoTherapy 3(Suppl 1): 84-85
1991
ISSN/ISBN: 1120-009X PMID: 12041795 Document Number: 374342
The effect of ethyl 2-methylthio-4-methyl-5-pyrimidine, carboxylate (S-7) on the infectivity and replication of herpes simplex virus type 1 in Vero cells was studied. S-7, at the highest concentration lacking toxic effect on cells (40 microg/ml), produced, at various inocula, a 40% inhibition of HSV-1 infectivity with respect to the plaque formation detected in control infected cultures. This inhibitory activity was substantiated by studies on progeny production. We cannot conclude that the inhibition of viral cytopathic effect resides in a specific inhibition of viral enzymes, however, the possibility of a more specific antiviral effect cannot be totally ruled out.