Role of host immunity on the efficacy of thiabendazole in rats infected with Nippostrongylus brasiliensis
Katiyar, J.C.; Misra, A.; Visen, P.K.
Wiadomosci Parazytologiczne 32(2): 163-172
1986
ISSN/ISBN: 0043-5163 PMID: 3727584 Document Number: 269525
The application of anthelmintics for control of parasitic infections is limited by a number of biological factors such as worm burden, age of infection, drug resistance and many others (Gibson, 1980; Misra et al., 1980). The beneficial effects of anthelmintics in practice, depend on their use in relation to known epidemiological and environmental factors (Gibson, 1980). Whereas, the mode of anthelmintics on parasitic invaders is well understood (Rew, 1978), the role of host during such antiparasitic chemotherapy can not be overlooked. The host exerts a number of effects on drugs influencing the effectiveness of therapy at many points along the route from administration of the substance to its eventual elimination. Earlier, we have reported the effect of certain biological factors on therapeutic efficacy of thiabendazole (TBZ)* using Nippostrongylus brasiliensis in rats as the test model (Misra et al., 1980). In this communication, we wish to communicate the therapeutic efficacy of TBZ under altered immunological conditions of the host.