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Heterogeneity of monospecific antibodies to the hemagglutinin of influenza virus H3N2 studied by radioimmunological analysis

Blokha, V.V.; Iamnikova, S.S.; Karpovich, L.G.; Iakhno, M.A.; Zakstel'skaia, L.I.

Voprosy Virusologii 29(6): 672-675

1984

ISSN/ISBN: 0507-4088
PMID: 6084896
Document Number: 223317
Heterogeneity of antibodies against influenza virus hemagglutinin has been confirmed. Various subpopulations of antibodies to the A/Khabarovsk/15/76 hemagglutinin were demonstrated some of which showed greater affinity to MRC-11 hemagglutinin than to the HA of the strain inducing this antibody synthesis. Apparently subpopulations of antibodies with low affinity to their "own" epitopes in the hemagglutinin-immunogen may develop which, however, may show a sufficiently high affinity to these epitopes in hemagglutinins of other strains.

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