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Antigenic and biochemical analysis of the proteins of influenza virus A/USSR/Alma-Ata/13/81 with hemagglutinin H1

Chuvakova, Z.K.; Fursova, L.M.; Kim, E.V.; Dotsenko, G.N.; Isaeva, E.I.

Voprosy Virusologii 29(6): 667-672

1984

ISSN/ISBN: 0507-4088
PMID: 6528572
Document Number: 230795
An influenza A virus whose hemagglutinin belongs to subtype H1 (serovariant WS/33) and neuraminidase to subtypes N1 (serovariant A/PR8/34) N3 was isolated by a method of aborted infection in chick embryos in virological examinations of the lungs and trachea of a 3-month-old infant who died of acute respiratory virus disease during a seasonal rise of ARD incidence in Alma-Ata, the Kazakh SSR, in 1981. The oligopeptide composition of nucleoprotein protein and glycoproteins of the isolate differed from that of the corresponding proteins of the reference serovariants. The electrophoretic analysis of the isolate polypeptides revealed neuraminidase with molecular weight about 70 kD which is unlike the findings with previously known strains. The original structure of the influenza A/USSR, Alma-Ata/13/81 virus proteins rules out the likelihood of laboratory contamination.

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