Experimental infection of lambs with ovine adenovirus isolate RTS-151: lesions
Cutlip, R.C.; Lehmkuhl, H.D.
American Journal of Veterinary Research 44(12): 2395-2402
1983
ISSN/ISBN: 0002-9645 PMID: 6318616 Document Number: 204304
Twelve young lambs, inoculated with ovine adenovirus isolate RTS-151, were killed 2-21 days after inoculation. Lesions were found only in the respiratory tract and were most severe in the terminal airways. Many cells of the respiratory epithelium had severe cytomegaly and karyomegaly with intranuclear inclusions. Desquamation of affected cells was accompanied by hyperplasia of airway and alveolar epithelium and by accumulation of necrotic cellular debris and neutrophils in terminal airways and alveoli. Virus replicated in the nucleus of enlarged epithelial cells in the airways, but not in alveolar epithelium. Intranuclear inclusions representing viral replication progressed from clumps of finely granular material without virions to a granular material with virions and finally to a dense inclusion with numerous virions.