Experimental production of lesions in canine pulmonary arteries similar to those produced by Dirofilaria immitis infection
Atwell, R.B.; Buoro, I.B.; Sutton, R.H.
Veterinary Record 116(20): 539-541
1985
ISSN/ISBN: 0042-4900 PMID: 3892873 Document Number: 255667
Pulmonary arterial disease was produced by the placement of flexible polyvinyl chloride threads (similar in size, shape and flexibility to adult female D. immitis) in the pulmonary arteries of dogs. Several different types of pathological change were apparent, ranging from subendothelial oedema and endothelial loss, mild intimal proliferation and thrombus formation to organized fibrous encasement of the threads in areas where they had become impacted in the lumen of the artery. This range of pathological changes is very similar to that produced by D. immitis and suggests that the intima of the canine pulmonary artery may react to different insults in a similar way.