Experimentally-induced osteoarthritis in guinea pigs: effect of surgical procedure and dietary intake of vitamin C
Schwartz, E.R.; Leveille, C.; Oh, W.H.
Laboratory Animal Science 31(6): 683-687
1981
ISSN/ISBN: 0023-6764 PMID: 6896353 Document Number: 182536
The effect of variation in dietary ascorbic acid on surgically induced osteoarthritis was examined in the stifle joints of guniea pigs. Two different surgical procedures were used to induce osteoarthritis in the right stifle joint of these animals. Guinea pigs were maintained either on a high (150 mg/day) or low (2.4 mg/day) dietary intake of vitamin C. Regardless of the surgical procedure used to induce osteoarthritis, the animals maintained on the high level of vitamin C consistently showed severe joint damage than animals on the low level of the vitamin.