Biochemical and immunological changes in guinea pigs with experimentally reproduced amyotrophic leukospongiosis
Votiakov, V.I.; Kolomiets, N.D.; Luchko, V.P.; Kolomiets, A.G.
Biulleten' Eksperimental'noi Biologii i Meditsiny 103(3): 292-294
1987
ISSN/ISBN: 0365-9615 PMID: 3828505 Document Number: 296254
Biochemical blood serum tests at different stages of amyotrophic leukospongiosis have shown differences in lactate and pyruvate levels as well as in lactate dehydrogenase activity, indicative of the increased oxidative exchange in sick guinea-pigs. It is suggested that intensified glycolysis is a compensatory-adaptive reaction in response to hypoxia due to respiratory disorders (spinal type) and degeneration and death of motoneurons. Leukospongiosis was accompanied by the decline in the complement level in the blood serum and production of antibodies to nervous fiber proteins.