Effect of dietary methionine and inorganic sulfate with and without calcium supplementation, on urinary calcium excretion of guinea pigs (Cavia porcellus)
Singh, P.P.; Hussain, F.; Gupta, R.C.; Pendse, A.K.; Kiran, R.; Ghosh, R.
Indian Journal of Experimental Biology 31(1): 96-97
1993
ISSN/ISBN: 0019-5189 PMID: 8500822 Document Number: 418172
Supplementation of sodium sulfate and DL-methionine along with the standard diet to guineapigs nearly doubled urinary calcium in 6 weeks. This was probably due to decreased tubular reabsorption of calcium which was complexed with sulfate in the tubular lumen. A mild calcium load didn't further enhance calcium excretion in the sodium sulfate supplemented group, but did so in the methionine supplemented group. Methionine may have increased the intestinal absorption of calcium. Both of these compounds increased citric acid excretion and decreased magnesium excretion.