Effect of hydrocortisone and insulin on changes of oxidative phosphorylation after neutron irradiation
Sutkovoĭ, D.A.; Alferov, A.N.; Baraboĭ, V.A.; Letov, V.N.
Ukrainskii Biokhimicheskii Zhurnal 51(3): 226-230
1979
ISSN/ISBN: 0201-8470 PMID: 462589 Document Number: 151963
Total double irriadiation of rats with a fast neutron flow does not affect oxidative phosphorylation in the liver mitochondria but causes an essential decrease in the intensity of phosphorylation in mitochondria and chemiluminescence in blood serum of animals. Postradiation multiple administration of hydrocortisone intensifies the radiation inhibition of oxidation and phosphorylation of mitochondria and insulin administration stimulates phosphorylation in the liver mitochondria and the intensity of chemiluminescence in blood serum of rats. Hydrocortisone in combination with insulin has a less pronounced stimulating effect on phosphorylation than insulin, but the intensity of chemiluminescence in this case is higher than under the effect of each preparation separately.