Regulation of oxidative phosphorylation by adrenaline and insulin, effect of the insulin-dependent cytoplasmic factor
Uzssr, A.N.; Turakulov, I.K.; Gaĭnutdinov, M.K.; Lavina, I.I.; Akhmatov, M.S.
Biulleten' Eksperimental'noi Biologii i Meditsiny 88(9): 301-304
1979
ISSN/ISBN: 0365-9615 PMID: 519021 Document Number: 149899
The insulin-dependent cytoplasmic factor-regulator (IDR) was shown to inhibit pyruvate and succinate oxidation by the rat liver mitochondria. In view of the fact that insulin increases and adrenaline decreases IDR activity in the liver cytoplasm it is suggested that oxidation of the substrate in mitochondria in vivo is regulated by changes in IDR content in cytoplasm. It was shown that adrenaline-activated oxidation apart from decreased activity of IDR in cytoplasm is induced by a different mechanism not related to IDR content.