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Intracellular metabolism in patients with insulin-dependent and non-insulin-dependent diabetes mellitus

Iakovlev, G.M.; Kozhemiakin, L.A.; Rakov, A.L.; Drygin, A.N.; Iakovlev

Problemy Endokrinologii 37(2): 11-14

1991

ISSN/ISBN: 0375-9660
PMID: 1857691
Document Number: 369806
Slow infusion of neutral insulin causes in patients with insulin dependent and noninsulin dependent diabetes mellitus diverse changes in the levels of cAMP, cGMP and the cAMP/cGMP ratio in leukocytes in spite of one-type changes in the concentration of contrainsular hormones in the venous blood: in patients with noninsulin dependent DM a raised cAMP/cGMP factor was lowered whereas in patients with insulin dependent DM it was increased. The authors put forward for discussion the problem of the postreceptor mechanisms of tissue insulin resistance in noninsulin dependent DM and a possibility of the use of the above indices for differential diagnosis of DM types.

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