Effect of oxidative phosphorylation inhibitors and uncoupling agents on cAMP activity
Liberman, E.A.; Minina, S.V.; Miakotina, O.L.; Shklovskiĭ-Kordi, N.E.
Biofizika 32(3): 522-524
1987
ISSN/ISBN: 0006-3029 PMID: 3040130 Document Number: 290365
Uncouplers of oxidative phosphorylation increased the speed of substrate oxidation and ATP hydrolysis and raised cAMP induced neuron membrane current. Different inhibitors decreased it. Both effects support the hypothesis that a signal of intracellular injected cAMP spreads to the neuron membrane as a mechanical signal. This signal propagated to the membrane along microtubules which according to this hypothesis serve as a sound generator with metabolic heat pumping.
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