Effect of exhaustive swimming on the oxidative phosphorylation and the activity of some enzymes in rat liver mitochondria
Radeva-Domustchieva, D.; Russanov, E.
Acta Physiologica et Pharmacologica Bulgarica 2(1): 72-77
1976
ISSN/ISBN: 0323-9950 PMID: 1015305 Document Number: 96937
In liver mitochondria of control animals , ATP-ase and cytochrome oxidase, as well as oxygen uptake, respiratory control index and ADP/O ratio upon oxidation of succinate and glutamate + malate. Decrease of the ADP/O ratio and of the respiratory control index, as well as increased ATP-ase activity, are established after swimming. The electron-transport rate decreases. The activity of the remaining enzymes is unchanged. The activities of MDH, SDH, NAD H-cytochrome c- and succinate-cytochrome c-oxireductases decrease 22 h after exhaustive swimming. The activities of the cytochrome oxidase and the ATP-ase are unchanged compared with the controls. A single exhaustive loading results in changes in the capacity of phosphorylation in the liver mitochondria, and the changes in the activities of the enzymes studied are established 22 h later.