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Antiviral activity of anomeric 5-substituted 2'-deoxyuridines

Bektemirov, T.A.; Chekunova, E.V.; Andzhaparidze, O.G.; Mel'nik, S.I.; Bakhmedova, A.A.

Voprosy Virusologii 6: 603-606

1979

ISSN/ISBN: 0507-4088
PMID: 524857
Document Number: 149601
The inhibiting effect for herpes and vaccinia viruses of 2'-deoxyuridine derivatives containing the substitute in the position of 5-pyrimidine ring was studied. Anomeric 5-isopropyl-2'-deoxyuridines were shown to produce a marked inhibiting effect in chick embryo fibroblasts infected with herpes virus and to have no effect on vaccinia virus replication, that is, to be specific antiherpetic agents. The alpha-anomer of 5-isopropyl-2'-deoxyuridine showed antiherpetic activity in vitro comparable with that of beta-anomer. Fifty per cent toxic doses and chemotherapeutic indices of the drugs under study were determined in comparison with those of 5-iod-2'-deoxyuridine.

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