Antiviral agents. 22. N-aliphatic, N-alicyclic and N-polycyclic substituted N'- (2-adamantyl) ureas and -thioureas
Kreutzberger, A.; Tantawy, A.
Arzneimittel-Forschung 33(4): 512-514
1983
ISSN/ISBN: 0004-4172 PMID: 6683528 Document Number: 214843
With reference to the role that (2-adamantyl), urea, and thiourea moieties play in antiviral drugs, these structural elements have been included in the present investigations aimed at the development of the N-substituted N'-(2-adamantyl)-thioureas 3a-d through the reaction of 2-aminoadamantane (1) with the isothiocyanates 2a-d. In an analogous manner, the interaction of 1 with the isocyanates 2e-f has led to the N-substituted N'-(2-adamantyl)ureas 3e-f. Within structure type 3 there occur representatives exhibiting antiviral, antimycotic, and herbicidal activity.