Substituted phenylacetylguanidines: a new class of antihypertensive agents
Bream, J.B.; Lauener, H.; Picard, C.W.; Scholtysik, G.; White, T.G.
Arzneimittel-Forschung 25(10): 1477-1482
1975
ISSN/ISBN: 0004-4172 PMID: 1243024 Document Number: 4648
The synthesis of a new series of phenylacetylguanidines is described. Several of them exhibited high antihypertensive activity in the rat. The most potent member of the series is N-amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride [2,6-dichlorophenylacetylguanidine hydrochloride, compound 19], which is now in clinical study under the clinical code number BS 100-141. The structure-activity relationships in this class of compounds are discussed.
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