Structure-activity relationships of dengue antiviral polycyclic quinones
Laurent, D.; Baumann, F.; Benoit, A.Gaelle.; Mortelecqe, A.; Nitatpattana, N.; Desvignes, I.; Debitus, Cécile.; Laille, M.; Gonzalez, J-Paul.; Chungue, E.
Southeast Asian Journal of Tropical Medicine and Public Health 36(4): 901-905
2005
ISSN/ISBN: 0125-1562 PMID: 16295543 Document Number: 586602
The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation.