Structure-activity relationships of halogenated phenylethanolamine and phenoxypropanolamine
Bercher, H.; Grisk, A.
Acta Biologica et Medica Germanica 35(1): 79-85
1976
ISSN/ISBN: 0001-5318 PMID: 10706 Document Number: 98652
Compounds (12) from the series of halogenated phenylethanolamines and phenoxypropanolamines were tested on the isolated rabbit jejunum, and the pD2, which stimulates the .alpha.-receptors, all compounds still have pronounced .beta.-mimetic effects. The 2,5-dihalogenated phenylethanolamines and phenoxypropanolamines block the .beta.-receptors at lower concentrations than 2,4-dihalogen derivatives. The weakest .beta.-adrenolytic effects at the intestine were found with compounds halogenated at the 3,4-position.