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Influence of the substituent radicals in antimonyl naphthalein derivatives on the potentialities of anti-schistosomal activity in mice

Ghaleb, H.A.; Shoeb, H.A.; el-Gawhary, N.; el-Borolossy, A.W.; el-Halawany, S.A.; Madkour, M.K.

Journal of the Egyptian Medical Association 62(1-2): 31-43

1979

ISSN/ISBN: 0013-2411
PMID: 262474
Document Number: 148082
Two naphthalein antimonial compounds were tested against Schistosoma mansoni in Swiss albino mice infected 49 days previously (100 to 130 cercariae/mouse). Antimonyl-2-hydroxy-1,3-sodium dicarboxy naphthalein displayed weak activity comparable to that of tartar emetic at 2 mg/kg body-weight. Antimonyl-2-hydroxy-3 carboxy-1-sodium acrylate naphthalein showed no antischistosomal activity.

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