Anti-implantation activity of 2 derivatives of o-hydroxy naphthaquinones in rats
Dhar, S.K.; Mattu, S.
Zhongguo Yao Li Xue Bao 16(5): 471-472
1995
ISSN/ISBN: 0253-9756 PMID: 8701772 Document Number: 454708
AIM: To search for female contraceptive agents. METHODS: 2-Hydroxy-3-methyl-1,4-naphthoquinone monosemicarbazone (HMNQS) and 2-hydroxy-1,4-naphthoquinone monothiosemicarbazone (HNQTS) were screened for anti-implantation activity in rats. RESULTS: Both compounds showed a dose-dependent activity, and HNQTS was more potent. An 100% anti-implantation activity was observed with HNQTS 150 mg kg-1 ig. Its LD-50 was found to be gt 2 g kg-1 ig in mice. CONCLUSION: HNQTS was more potent than HMNQS for anti-implantation activity in rats.
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