Intracerebral implantation of the anti-estrogen CN-69, 725-27: Effects on female sexual behavior in rats
Luttge, W.G.
Pharmacology Biochemistry and Behavior 4(6): 685-688
1976
ISSN/ISBN: 0091-3057 PMID: 981285 DOI: 10.1016/0091-3057(76)90220-3Document Number: 430596
Ovariectomized adult female rats were stereotaxically implanted with double walled cannulas (22 ga outer and 27 ga inner) and tested for sexual receptivity (lordosis behavior) following SC estradiol benzoate and progesterone priming. Implantation of the anti-estrogen CN-69,725-27 (c. 65 mug) immediately after the first of 3 daily estrogen injections produced a dramatic inhibition of sexual receptivity when these implants were placed in the preoptic and anterior hypothalamic areas. CN-69,725-27 implants had no effect on receptivity when implanted in the middle hypothalamus, mesencephalon or frontal cortex. All inhibitory effects of the anti-estrogen were reversible within one day after removal of the CN-69,725-27 cannula from the brain.