Effects of 5-HT1 and 5-HT2 serotonin receptors on anxiety- and depression-like behavior in female rats
Fedotova, I.O.
Eksperimental'naia i Klinicheskaia Farmakologiia 74(3): 6-9
2011
ISSN/ISBN: 0869-2092 PMID: 21598629 Document Number: 654664
The influence of the chronic (14-day) administration of 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and 5-HT2B/2C receptor agonist m-CPP (0.5 mg/kg, i.p.) on the anxiety- and depression-like behavior has been studied in adult female rats during key phases of the ovarian cycle. The chronic administration of m-CPP at the estrous phase produced an anxiolytic effect, while at the proestrous phase, the same drug produced an anxiogenic effect. At the same time, both 8-OH-DPAT and m-CPP exhibited pronounced antidepressant effect irrespective of the ovarian cycle phase.