Participation of D (1) -receptors in anxiety-depression-like behaviour in female rats for ovary cycle
Fedotova, I.O.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 3: 30-33
2010
ISSN/ISBN: 0031-2991 PMID: 20853618 Document Number: 645123
The present work was devoted to the comparative analysis of influence of chronic administration of D(1)-receptors agonist - SKF-38393 (0,1 mg/kg, i.p.) and D1-receptors antagonist - SCH-23390 (0,1 mg/kg, i.p.) for 14 days on anxiety and depressive-like behavior in the adult female rats. Model of depression in rats was carried out in Porsolt test. Anxiety level was assessed in the elevated plus maze. It was established that SCH-23390 rendered antidepressive and anxiolytic effects in females during estrous and proestrous. SKF-38393 resulted in prodepressive effect in estrous and proestrous. Also, it was noted definite modulation of anxiety behavior in connection of ovary cycle phases in rats treated with SKF-38393: at increased level of estrogens was anxiolytic effect while at reduced level of estrogen - anxiogenic effect. It is suggested different extent of D1-receptors receptors involvement in the mechanisms of anxiety-depressive-like behavior at alterations of hormonal balance during ovary cycle.