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The effect of MK-801 and imipramine on beta-adrenergic and 5-HT2 receptors in the chronic mild stress model of depression in rats

Klimek, V.; Papp, M.

Polish Journal of Pharmacology 46(1-2): 67-69

1994

ISSN/ISBN: 1230-6002
PMID: 7981774
Document Number: 432020
Chronic exposure (8 weeks) to sequential application of mild stressors caused the increase in the density (B-max) of beta-adrenergic and 5-HT-2 receptors in the rat cerebral cortex. MK-801 given chronically (5 weeks) decreased beta-adrenergic receptors density in both control and stressed rats, whereas it decreased the density of 5-HT-2 receptors in control rats only. On the other hand, imipramine administered for 5 weeks reduced the number of beta-adrenergic and 5-HT-2 receptors in both control and stressed rats.

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