Effects of chronic histamine and ovalbumin aerosols on pulmonary beta adrenergic receptors in sensitized guinea pigs
Cheng, J.B.; Townley, R.G.
Research Communications in Chemical Pathology and Pharmacology 36(3): 507-510
1982
ISSN/ISBN: 0034-5164 PMID: 6289398 Document Number: 185510
Using (3H) dihydroalprenolol, we demonstrated that the concentration of pulmonary beta adrenergic receptor binding sites was lower in guinea pigs showing a marked bronchoconstrictive response to histamine and in ovalbumin-treated guinea pigs. This result suggests that the changed concentration of the pulmonary beta receptors in an animal model of asthma could be resulted from bronchoconstriction stress.