Serotonin-mediated behavior in rats chronically treated with (-) deprenyl
Gyarmati, S.; Timar, J.; Knoll, B.; Knoll, J.
Polish Journal of Pharmacology and Pharmacy 40(6): 667-671
1988
ISSN/ISBN: 0301-0244 PMID: 2479936 Document Number: 316256
(-) Deprenyl given in small (0.25 mg/kg) daily doses for 30 days to rats left the serotonin (5-HT) and the 5-hydroxyindoleacetic acid (5-HIAA) levels in the striatum unchanged. The postsynaptic 5-HT receptor responsiveness, as measured with 5-methoxy-N,N-dimethyl-tryptamine (5-MeODMT), remained also unaltered. In (-) deprenyl-treated rats the p-chloroamphetamine (PCA)-induced 5-HT syndrome was significantly increased and this enhancement of the PCA effect was not abolished by the reserpine-induced depletion of the 5-HT stores.