Enhanced responses to muscarine in rats treated chronically with atropine
Herman, Z.S.; Słomińska-Zurek, J.
Polish Journal of Pharmacology and Pharmacy 33(5): 481-484
1981
ISSN/ISBN: 0301-0244 PMID: 7335552 Document Number: 181050
Rats were treated for 14 or 30 days with 10 mg/kg sc atropine (AT) daily. 24 h after the last dose of At, 50 micrograms of muscarine (MU) was injected intracerebroventricularly (ivtr.). Long-term atropinization enhanced the behavior induced by MU. These data support our previous suggestion that chronic blockade of central muscarinic receptors induces their hypersensitivity.
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