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Effects of pirenzepine and atropine on gastric secretory and plasma hormonal responses to sham-feeding in patients with duodenal ulcer

Konturek, S.J.; Obtulowicz, W.; Kwiecień, N.; Dobrzańska, M.; Swierczek, J.; Kopp, B.; Olesky, J.

Scandinavian Journal of Gastroenterology. Suppl 66: 63-69

1980

ISSN/ISBN: 0085-5928
PMID: 6941379
Document Number: 160521
The effects of atropine and pirenzepine on sham-feeding stimulated gastric secretion and serum gastrin and pancreatic polypeptide levels have been studied in 12 patients with duodenal ulcer. Both atropine and pirenzepine caused a dose-dependent decrease in acid and pepsin secretion induced by sham-feeding. Serum gastrin response to sham-feeding was negative and it was enhanced by atropine but suppressed by pirenzepine. Plasma pancreatic polypeptide level, which was markedly increased by sham-feeding, was abolished both by atropine and pirenzepine. This study shows that pirenzepine is a more selective inhibitor of gastric secretory and serum hormonal responses to sham-feeding than atropine and that it may be a useful tool for studying the cholinergic innervation of the oxyntic glands and the G-cells in man.

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Forichon, J.; Minaire, Y.; Vagne, M.; Sicallac, P.; Chayvialle, J.A. 1986: Effects of proximal gastric vagotomy on gastric secretory and plasma hormonal responses to sham feeding in patients with duodenal ulcers Hepato-Gastroenterology 33(3): 115-119
Olbe, L.; Knutson, U. 1976: Gastric acid response to sham feeding in the dog and the duodenal ulcer patient Acta Hepato-Gastroenterologica 23(6): 455-458
Nilsson, G. 1975: Increased plasma gastrin levels in connection with inhibition of gastric acid responses to sham feeding following bulbar perfusion with acid in dogs Scandinavian Journal of Gastroenterology 10(3): 273-277
Borisov, I.I.; Fisher, A.A. 1992: The rheology of the gastric mucus and the secretory activity of the main gastric glands in patients with duodenal peptic ulcer Likars'ka Sprava 10: 42-45
Bayeli, P.F.; Benelli, R. 1982: Pirenzepine in gastric and duodenal ulcer: randomized comparison with cimetidine La Clinica Terapeutica 102(2): 139-152
Bassalyk, L.S.; Meshcheriakova, S.A.; Melikova, M.I. 1972: Various humoral mechanisms of regulating the secretory function of the stomach in patients with gastric and duodenal ulcer Klinicheskaia Meditsina 50(6): 86-91
Meneghelli, U.G.; Troncon, L.E. 1988: Effect of pirenzepine on basal gastric acid and pepsin secretion and on secretion stimulated with graded doses of pentagastrin in duodenal ulcer patients Brazilian Journal of Medical and Biological Research 21(4): 781-789
Aliev, M.A.; Kashkin, K.A.; Darmenko, O.K.; Musabaev, N.K.; Shaĭmerdenova, K.G. 1983: Gastric secretory function before and in the early period after selective proximal vagotomy in duodenal ulcer patients Klinicheskaia Khirurgiia 10: 56-57
Hirschowitz, B.I.; Fong, J.; Molina, E. 1983: Effects of pirenzepine and atropine on vagal and cholinergic gastric secretion and gastrin release and on heart rate in the dog Journal of Pharmacology and Experimental Therapeutics 225(2): 263-268
Feldman, M.; Schiller, L. 1982: Effect of bethanechol (urecholine) on gastric acid and nonparietal secretion in normal subjects and duodenal ulcer patients. Comparison with atropine, pentagastrin, and histamine Gastroenterology 83(1 Part 2): 262-265
Fisher, A.A.; Borisov, I.I. 1989: Motor function of the stomach and small intestine and gastric secretory activity in smokers and alcoholic patients with duodenal ulcer Klinicheskaia Meditsina 67(3): 122-125
Ladha, L.L.; Choudhary, S.; Singh, S.; Chaplot, G.S. 1977: Study of secretory responses in normal and duodenal ulcer subjects Journal of the Association of Physicians of India 25(3): 205-210
Emås, S.; Svensson, S.O.; Dörner, M.; Kaess, H. 1976: Gastric acid and serum gastrin responses to insulin and 2-deoxy-d-glucose in duodenal ulcer patients before and after partial gastrectomy Scandinavian Journal of Gastroenterology 11(7): 667-672
Hayakawa, A.; Misawa, T.; Nishihara, S.; Kobayashi, S.; Bozler, G. 1987: Pharmacokinetics of pirenzepine in patients with gastric or duodenal ulcers Arzneimittel-Forschung 37(8): 980-982
Giovinetto, A.; Calì, R.; Ossino, C.; Giardina, N.; Rinella, P. 1976: Study of the behavior of gastric secretory function after proximal selective vagotomy for duodenal ulcer Chirurgia Italiana 28(4): 283-297
Lazzaroni, M.; Sangaletti, O.; Bianchi Porro, G. 1992: Gastric acid secretion and plasma gastrin during short-term treatment with omeprazole and ranitidine in duodenal ulcer patients Hepato-Gastroenterology 39(4): 366-370
Barberani, F.; Della Spoletina, A.; D'Ambrosio, C.; Schiaroli, G.; Fiorini, M.A.; Nicolao, V.; Carpinelli, D.; Valentini, P. 1986: Pharmacologic treatment of duodenal ulcer. Short and long-term results with pirenzepine in ambulatory patients Minerva Medica 77(42-43): 1997-2005
Lazzaroni, M.; Sangaletti, O.; Parente, F.; Imbimbo, B.P.; Bianchi Porro, G. 1986: Inhibition of food stimulated acid secretion by association of pirenzepine and ranitidine in duodenal ulcer patients International Journal of Clinical Pharmacology Therapy and Toxicology 24(12): 685-688
Okabe, S.; Tabata, K.; Kawakami, M. 1982: Effects of prolonged treatment of pirenzepine 2HCl on gastric secretion and plasma gastrin levels in rats Arzneimittel-Forschung 32(6): 664-668
Lebedeva, R.P.; Belostotskiĭ, N.I. 1987: Enzymatico-secretory function of the stomach in patients with duodenal ulcer Klinicheskaia Meditsina 65(4): 75-77