Gastric acid response to sham feeding in the dog and the duodenal ulcer patient
Olbe, L.; Knutson, U.
Acta Hepato-Gastroenterologica 23(6): 455-458
1976
ISSN/ISBN: 0300-970X PMID: 827178 Document Number: 102678
Physiological vagal activation in the duodenal ulcer patient produces a release of gastrin mainly from the antrum-bulb region. This gastrin release contributes to the gastric acid response but only to a minor degree and by an additive secretory effect. The gastrin release in response to physiological vagal activation seems to be absent in healthy subjects. The markedly augmentative effect of vagally released gastrin from the antrum in the dog on the gastric acid response to physiological vagal activation does not occur in the duodenal ulcer patient. Intragastric acidification slightly reduces the gastric acid response to physiological vagal activation in the duodenal ulcer patient probably due to blocked release of gastrin. Even during optimal conditions for release of gastrin from the antrum the gastric acid response to physiological vagal activation in the duodenal ulcer patient does not reach the maximal acid response to histamine or exogenous gastrin. The antrum-bulb region participates in maintaining the gastric acid secretory capacity of the duodenal ulcer patient, possibly due to a trophic effect of the antrum-bulb gastrin on the parietal cell region while the antrum of the dog rather suppresses the gastric acid secretory capacity.