Pancreatic polypeptide response to sham feeding in man
Koop, H.; Börger, H.W.; Becker, H.D.; Arnold, R.; Creutzfeldt, W.
Zeitschrift für Gastroenterologie 22(8): 394-399
1984
ISSN/ISBN: 0044-2771 PMID: 6485439 Document Number: 227100
The relationship between gastric acid secretion and the release of pancreatic polypeptide (PP) during modified sham feeding was studied in 29 duodenal ulcer patients and 10 healthy controls. Ulcer patients showed higher basal plasma PP levels than age-matched controls (p less than 0.01). Acid secretion and PP levels were stimulated in the majority of patients and controls during sham feeding; however, no correlation was found between basal and vagally stimulated acid secretion and basal PP levels. Gastrin levels did not change in both groups. It is concluded from the present study that changes in plasma PP levels do not reflect sham feeding induced stimulation of the parietal cells.