Biological characteristics of the plaque variants of the swine vesicular disease virus
Dilovski, M.
Veterinarno-Meditsinski Nauki 15(6): 15-20
1978
ISSN/ISBN: 0324-1068 PMID: 218333 Document Number: 132529
The Swine Vesicular Disease virus yields a heterogenic plaque population consisting of large round plaques of 8-10 mm, small uniform plaques with slightly indented contours, measuring 1-3 mm, and single plaques of transient form and size. The reisolates of the large (Lpf) plaques give a population that is similar to the initial virus, while the cloning of the small (Mpf) plaques leads to a homogenic population of such plaques. In vivo, the virus of the large plaques manifests enhanced virulence for swine. On the other hand, the selected small-plaque variant is apathogenic, which makes it possible to produce a live avirulent vaccine.