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Structural characteristics of a population of antigenic variants of the influenza A (H3N2) virus

Kolotvinov, S.V.; Manova, I.P.; Galitarov, S.S.; Sukhinin, V.P.

Voprosy Virusologii 32(4): 409-413

1987

ISSN/ISBN: 0507-4088
PMID: 3686981
Document Number: 286236
The data have been obtained indicating that clone distribution by the antigen avidity in the population of influenza A (H3N2) virus corresponds to normal distribution. The degree of avidity of individual strains is determined by the predominant content of clones with high or low avidity. Virus purification by ultracentrifugation in sucrose density gradient results in increasing the avidity of the preparation as compared with the original allantoic cultures. Defective virions may differ in avidity from intact viral particles of the same strain and in this way affect the "total" avidity of a virus preparation.

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