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Effect of formalin on antigenic properties of influenza virus

Zgorzelska, K.; Wilczyński, J.

Medycyna Doswiadczalna i Mikrobiologia 32(2): 103-111

1980

ISSN/ISBN: 0025-8601
PMID: 7464350
Document Number: 155490
Influenza virus strains were inactivated with formalin in concentrations used for the production of vaccines and diagnostics. Samples for testing were taken after 2 wk and 1, 3, 6 and 12 mo. of storage at 4.degree. C. HA titer and antigenic properties were tested with homologous and heterologous antisera. Over a period of time, HA titers of both A and B strains decreased. Antigenic specificity changed more quickly and clearly in strain B. When formalin is used for inactivation, a shorter exposure time should be used.

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Higashihara, M.; Igarashi, Y.; Saito, Y. 1976: Recombinant influenza-virus vaccines. IV. Segregation of antigenic and some biological properties of Influenza virus neuraminidase by recombination Kitasato Archives of Experimental Medicine 49(3): 81-91
Liozner, A.L.; Stepanova, E.N.; Volynskaia, N.A.; Vorkunova, G.K.; Bukrinskaia, A.G. 1985: Analysis of the antigenic and immunogenic properties of protein M of the influenza virus by an immunoenzyme method Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 3: 91-96
Dubrovina, T.I.; Egorov, A.I.; Ivanova, I.A.; Pokhil'ko, A.V.; Poliak, R.I. 1995: The effect of mutation in the NS gene on the biological properties of the influenza virus Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 3: 75-79
Chomik, M. 1986: Ultrastructure and some biological properties of influenza A virus. I. Alterations in the activity of surface antigens of influenza A virus by enzymes and infectious activity of such changed viruses Archivum Immunologiae et Therapiae Experimentalis 34(1): 49-57
Seleznev, E.A.; Simonov, A.N.; Tverdislov, V.A.; Kharitonenkov, I.G. 1990: Effect of influenza virus proteins on the physical properties of lipid bilayer membranes Biofizika 35(5): 880-881
Semenkov, V.F.; Ageeva, O.N.; Lavrov, V.F.; Korotkov, A.A.; Khodakova, L.P. 1985: Effect of the host's body genotype and phenotype on the manifestation of the pathogenic properties of the influenza virus Voprosy Virusologii 30(2): 159-163
Podchernyaeva RYa; Döhner, L.; Herrmann, R.M.; Blinova, V.K.; Ivanova, V.T. 1982: Studies on some genetic properties of antigenic recombinants of influenza viruses Acta Virologica 26(4): 227-233
Gorev, N.E. 1975: The effect of species and organ-specific features of tissue systems on the reactogenic and immunogenic properties of influenza virus Acta Virologica 19(1): 41-46
Prasad, A.K.; Czekalowski, J.W. 1975: Antigenic variation amongst influenza virus type C Indian Journal of Pathology and Microbiology 18(3): 169
Milovidova, N.I.; Porubel', L.A.; Ginzburg, V.P.; Gendon, I.Z. 1974: Antigenic and immunogenic activity of influenza virus virion components Voprosy Virusologii 6: 683-688
Vorkunova, G.K.; Dotsenko, G.N.; Bukrinskaia, A.G.; Zhdanov, V.M. 1979: Oligopeptide mapping of the antigenic drift of influenza virus hemagglutinins Voprosy Virusologii 4: 427-430
Markushin, S.G.; Ginzburg, V.P.; Khaĭder, A.M.; Iarosh, V.V.; Ivas'ko, E.A.; Klimov, A.I. 1992: Factors that cause a change in the antigenic structure of of the influenza virus hemagglutinin Voprosy Virusologii 37(4): 196-199
Kolotvinov, S.V.; Manova, I.P.; Galitarov, S.S.; Sukhinin, V.P. 1987: Structural characteristics of a population of antigenic variants of the influenza A(H3N2) virus Voprosy Virusologii 32(4): 409-413
Jung-ken, L. 1979: A simple method for testing antigenic variation of influenza virus antigenicity Chinese Medical Journal 92(1): 37-40
Chuvakova, Z.K.; Fursova, L.M.; Kim, E.V.; Dotsenko, G.N.; Isaeva, E.I. 1984: Antigenic and biochemical analysis of the proteins of influenza virus A/USSR/Alma-Ata/13/81 with hemagglutinin H1 Voprosy Virusologii 29(6): 667-672
Berezina, O.N.; Blokha, V.V.; Iamnikova, S.S.; Iakhno, M.A.; Zakstel'skaia, L.I. 1978: Antigenic specificity of influenza type a virus hemagglutinin by the method of radioimmunological quantitative analysis Voprosy Virusologii 2: 160-165
Khristova, M.L.; Busse, T.L.; Egorenkova, E.M.; Leonov, S.V.; Sokolova, M.V.; Gitelman, A.K.; Herrmann, J.; Döhner, L.; Kharitonenkov, I.G. 1989: Antigenic reactivity of matrix protein and nucleoprotein of influenza virus as detected by EIA after dissociation with different detergents Acta Virologica 33(1): 1-7
Blokha, V.V.; Iamnikova, S.S.; Karpovich, L.G.; Iakhno, M.A.; Zakstel'skaia, L.I. 1985: Radioimmunological study of the antigenic conformity of the hemagglutinins of vaccinal and epidemic strains of influenza virus Voprosy Virusologii 30(1): 24-27
Shilov, A.A.; Kozlov, I.V.; Chaĭka, O.V.; Kurmanova, A.G.; Zhdanov, V.M. 1987: Genetic variability of epidemic strains of influenza virus serotypes H1N1 and H3N2 during antigenic drift Voprosy Virusologii 32(4): 419-429
Shu, Y.-l.; Zhang, Y.; Wen, L.-y.; Li, Z.; Guo, J.-f.; Wang, M.; Yu, H.-j.; Yang, W.-z.; Guo, Y.-j. 2005: Antigenic and genetic study of hemagglutinin gene of influenza virus (H3N2) circulated in China in 2004 Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 19(4): 362-365