Prevalence of non-T-cells in the replication of the N-tropic, type C virus of young AKR mice

Gisselbrecht, S.; Blaineau, C.; Hurot, M.A.; Pozo, F.; Levy, J.P.; Gisselbrecht, S; Blaineau, C; Hurot, M.A; Pozo, F; Levy, J.P

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Prevalence of non-T-cells in the replication of the N-tropic, type C virus of young AKR mice

Gisselbrecht, S.; Blaineau, C.; Hurot, M.A.; Pozo, F.; Levy, J.P.

Cancer Research 38(4): 939-941

1978

ISSN/ISBN: 0008-5472

PMID: 205350

Document Number: 130978

The XC infectious center assay was used to study the nature of the lymphoid cells producing N-tropic C-type viruses in preleukemic AKR mice. Viral production by thymic cell suspensions was very low and was possibly due to contaminating cells. Production at least 100-fold higher was found in spleen cells and was probably due to non-T-cells. The significance of these results is discussed briefly, including the possibility that the N-tropic XC syncitia-inducing type C virus of young AKR mice is not the leukemogenic agent.